The chemokine kidnapping receptor of HHV8.

Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.

ORF74 (or KSHV-vGPCR) is a highly constitutively active G protein-coupled receptor encoded by HHV8 that is regulated both positively and negatively by endogenous chemokines. When expressed in transgenic mice, this chemokine receptor induces an angioproliferative disease closely resembling Kaposi sarcoma (KS). Here we demonstrate that several lines of mice carrying mutated receptors deficient in...

Bride Kidnapping in Kyrgyzstan

This paper provides an economic analysis of the practice of bride kidnapping in Kyrgyzstan based on a Beckerian model of family fertility and consumption. Bride kidnapping is considered to be a way of marrying a wife at lower cost. In our settings, bride kidnapping is rational behavior for an elder generation that values offspring more than does the younger generation. In existence of bride kid...

Kidnapping and the limits of acceptance

For many humanitarian agencies, acceptance—gaining the trust and protection of local communities—is the preferred security management tool for reasons of perception, ease of access and cost (both real and opportunity costs). Humanitarian agencies have long been uncomfortable with the contradiction of using deterrence mechanisms in humanitarian operations, although the increased use of armed gua...

The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3.

We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine, which binds to a CXC chemokine receptor. L...

The Chemokine Receptor CXCR3 Attenuates